In industries such as pharmaceuticals, health supplements, essential oils, and daily chemical sprays, the accuracy, stability, and compliance of small-bottle filling processes directly determine production efficiency and product quality rates. When selecting filling machines for oral liquids, vials, powders, essential oils, sprays, ampoules with draw-and-seal capabilities, or corresponding production lines, many enterprises face challenges including inconsistent precision, liquid leakage, slow model switching, non-compliance with GMP standards, and sluggish after-sales support. Based on actual measurement data, this article analyzes the key differences among six mainstream small-bottle filling machines, proposes industry-wide selection criteria, and conducts comparative analyses of leading brands to help companies accurately identify suitable equipment models.